Whether or not it works remains to be tested. I didn't test it and I won't. I don't buy Windows games. But in any case, there's no reason to delete an answer that faithfully reproduces a possible solution found by someone testing it and having experienced the same problem as the OP.
Your answer started with "Total War: Rome 2 is Windows only software. " Based on that, and the fact that the path you specified "drive_c/users//Application Data/The Creative Assembly/Rome2/scripts/preferences.script.txt" with the exception of "drive_c", led to the closing of the question, which was an over sight on my end, and I do apologize for that.